|Beitragstitel||Localization of second primary malignancies in oropharyngeal squamous cell carcinoma survivors|
Localization of second primary malignancies in oropharyngeal squamous cell carcinoma survivors
INTRODUCTION: HPV infection is a novel risk factor for oropharyngeal squamous cell carcinomas (OPSCC). The HPV epidemics has led to an increasing incidence of OPSCC, meanwhile HPV-negative OPSCC cases associated with smoking and alcohol remain stable. As HPV-positive and -negative OPSCC present two distinct aetiological, clinical and prognostic entities, different treatment and follow-up strategies are being discussed. Specific surveillance strategies for HPV-positive OPSCC are lacking as the risk of second primary malignancies (SPM) in the era of HPV-associated OPSCC has not been comprehensively assessed.
METHODS: We performed a retrospective chart analysis of 107 OPSCC patients treated at the Zurich University Hospital from 2001 to 2010. Rate and localization of second primary malignancies after an index OPSCC were stratified according to smoking and HPV-infection status.
RESULTS: The mean age of diagnosis was 59.4 years (SD ±9.41y). 61 of 107 OPSCC patients (57%) tested positively for HPV. Smoking OPSCC patients had a higher rate of SPM than non-smoking HPV-positive OPSCC. The most common sites for SPM were another head and neck location and the lungs.
CONCLUSION: As expected, the vast majority of SPMs of HPV-negative patients were localized in the upper aerodigestive tract, due to smoking associated field cancerization.
Salome L. Bosshart1, Grégoire B. Morand1, Martina A. Broglie1
1UniversitätsSpital Zürich, Department of Otorhinolaryngology – Head and Neck Surgery, Zurich, Switzerland