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Beitragstitel A case of isolated laryngeal plasmacytoma with secondary amyloidosis in a 54 y/o patient
Beitragscode P25
  1. Hannes Brandt Kantonsspital Aarau AG Präsentierende:r
  2. Nora Tetter Kantonsspital Aarau AG
  3. Steffi Johanna Brockmeier Kantonsspital Aarau
Präsentationsform Poster
  • SGORL FV 2019
Abstract-Text In this contribution we present a rare case of dysphonia in a female patient, highlighting the challenges associated with its initial diagnosis, the essential steps of workup and the involved treatment modality.

A 54y/o otherwise healthy female was referred to us by a local speech therapist with hoarseness which had progressed over a period of 8 months and had not responded to speech therapy. She denied any history of smoking or alcohol abuse. Laryngostroboscopy showed normal true vocal folds with full closure at phonation and symmetrical movement. The false vocal folds were unusually prominent with intact mucosa and hesitant movement on the right side. Voice quality was rated R2B0H0. Additional diagnostic measures included magnetic resonance imaging (MRI) and computed tomography of the neck which displayed a unilateral infiltrating mass of the right vestibular fold eroding the thyroid cartilage. Rigid endoscopy and biopsy were performed. Histologic specimens demonstrated plasmacytoma in the right-sided arytenoid mucosa and amyloid deposits in the right vestibular fold. Workup including urine and blood analysis, bone marrow biopsy, positron emission tomography and full body MRI revealed no evidence of systemic disease. With the diagnosis of an isolated supraglottic plasmacytoma of the larynx with secondary amyloidosis curative therapy with radiation therapy (50 Gy over 5 weeks) was initiated. The patient is currently awaiting restaging.

Isolated laryngeal plasmacytoma is a rare cause of dysphonia and should be considered in a patient presenting with chronic hoarseness. As systemic disease may develop years after local curative therapy, long term follow up is indicated.